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KMID : 0438219760130020221
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Korea University Medical Journal
1976 Volume.13 No. 2 p.221 ~ p.229
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The Influences of Iproniazid and Pyrogallol on the toxicity of reserpine
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Abstract
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Reserpine is widely used in mental disease and hypertension. It evokes a tranquilizing action on the cerebrum which appears to be produced by smaller doses than that required for hypertension. We usually experience some side effects and toxic actions of reserpine in clinical use, and so the author attempted to find out the antidotal agent for reserpine toxicity.
It is well known that reserpine releases catecholamines from the sympathetic innervated organs in small doses, and depletes them in large doses. The catecholamines are usually metabolized by monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT). It is postulated that iproniazid is a MAO inhibitor, and pyrogallol is a COMT inhibitor.
The author, therefore, attempted to investigate the influences of iproniazid and pyrogallol on the toxic effects of reserpine on mice and also the effects of reserpine on the blood sugar concentration, serum total cholesterol, and serum transaminase (GOT, GPT) activities of rabbits pretreated with iproniazid or pyrogallol.
Two groups of rabbits were pretreated; via intraperitoneal injection, one group received a single dose of iproniazid 20mg/kg, and the other group received a single dose of pyrogallol 30mg/kg. Both groups were then administered reserpine 0.5 mg/kg intraperitoneally.
The results obtained are summarized as follows:
1. The LD,0 of reserpine on mice pretreated with iproniazid or pyrogallol was increased, especially in the mice pretreated with iproniazid.
2. The blood sugar concentration of normal rabbits was decreased by iproniazid or pyrogallol injection, but the blood sugar concentration changed slightly by reserpine alone, was inclined to be decreased by pretreatment of iproniazid or pyrogallol, and especially, the blood sugar concentration was increased 6 hours after the pretreatment of pyrogallol, but after 48 hours, it was decreased.
3. The serum total cholesterol concentration of normal rabbits was not influenced by iproniazid or pyrogallol injection, but the serum total cholesterol concentration increased by reserpine alone was markedly decreased 6 hours after the pretreatment of iproniazid or pyrogallol, but after 48 hours, it was increased.
4. The serum GOT activities of normal rabbits were inclined to be decreased by iproniazid or pyrogallol injection, but the serum GOT activities decreased by reserpine alo-ie were increased by pretreatment of iproniazid or pyrogallol.
5. The serum GPT activities of normal rabbits were not influenced by iproaiazid or pyrogallol injection, and also the serum GPT activities changed slightly by reserpine alone were not influenced by pretreatment of ipronazid d or pyrogallol.
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